Sri Sai College provides well-equipped Computer Science laboratories designed to offer students practical exposure to modern computing technologies. The department has three fully established laboratories with nearly 100 computer systems connected through a Local Area Network (LAN), creating an efficient and collaborative learning environment.

The first laboratory is equipped with 30 advanced systems featuring the latest configurations and is connected to a dedicated server operating in both Unix and Windows environments. The other two laboratories are integrated with internal servers through Novell NetWare, enabling seamless access to various networking platforms and software applications.

All three laboratories are interconnected to provide students with hands-on experience in different networking environments, programming tools, and software technologies. The labs are also enabled with Internet connectivity, supporting research, project work, and interactive learning.

The Department of Microbiology at Sri Sai College has successfully completed seven years of dedicated academic service, providing students with quality education and practical learning experiences in the field of microbiology.

The laboratory is well-equipped with modern instruments and facilities, including an Autoclave, Incubator, Inoculation Chamber, UV Chamber, Spectrophotometer, Colorimeters, and a Distillation Unit. These advanced facilities enable students to gain hands-on training, conduct experiments effectively, and develop strong practical and research-oriented skills in microbiology.

The Physics Department at Sri Sai College is equipped with well-structured laboratories that provide students with extensive practical exposure in various branches of physics. The department features two specialized laboratories designed to support both foundational and advanced scientific experiments.

The first laboratory is equipped with instruments and apparatus related to Mechanics, Heat, Modern Physics, and Electronics, enabling students to perform a wide range of practical experiments and applications.

The second laboratory includes a dedicated darkroom facility for conducting experiments related to Optics, helping students gain hands-on understanding of light-based phenomena and optical principles.

The college has also acquired advanced scientific equipment such as Photocells, Spectrophotometers, Traveling Microscopes, Optical Benches, and several other laboratory instruments to enhance the learning experience.

Keeping pace with global advancements in science and technology, Sri Sai College introduced the Biotechnology course with a well-established and fully equipped laboratory to provide students with comprehensive practical training and research exposure.

The Biotechnology laboratory is furnished with advanced equipment such as a Horizontal Laminar Airflow Bench, Slab Gel Electrophoresis Unit, Incubator, Hot Air Oven, Autoclave, Single Pan Balance, Electronic Balance, Digital pH Meters, Remi Revolutionary High-Speed Centrifuge, UV Spectrophotometer, Chromatography Chambers with accessories, Water Still, and Remi Magnetic Stirrer with Hot Plate, among others.

The laboratory was established under the expert guidance of Dr. Kavi Kishore, Professor and In-charge of the Biotechnology Course at Osmania University. The facility enables students to gain hands-on experience in modern biotechnological techniques, experimental procedures, and scientific research practices.

The Chemistry Department at Sri Sai College is supported by well-equipped laboratories designed to provide students with strong practical knowledge and hands-on scientific training. The department includes two Chemistry laboratories along with a dedicated Semi-Micro Analysis Lab and a Balance Room to facilitate advanced experimental learning.

The first laboratory is primarily used for Organic Synthesis and Functional Group Analysis, and is equipped with chromatography chambers and related accessories to support detailed chemical experimentation and analysis.

The second laboratory is furnished with all the essential apparatus required for volumetric analysis and practical chemistry experiments. Both laboratories are equipped with modern gas connection facilities to ensure safe and efficient laboratory operations.

To enhance practical learning and research capabilities, the department also provides advanced instruments such as a Digital pH Meter, Spectrophotometer, Digital Conductometer, Centrifuge Machine, and Single Pan Balance. In addition, distillation units are installed in each laboratory to support various analytical and purification processes.